METABOLIC THERAPY

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600 people with blood cancer receive innovative new treatment on the NHS

Cutting-edge Car T-cell Therapy Approved by NHS to Transform Treatment for Aggressive Blood Cancer
Overview

The NHS in England has approved a ground-breaking new treatment for aggressive blood cancer, known as Lisocabtagene maraleucel (liso-cel or Breyanzi). This innovative therapy involves modifying a patient’s T-cells to specifically target and kill cancer cells, offering new hope to nearly 600 patients annually. The treatment has shown significant promise in clinical trials, delaying disease progression and potentially improving patients’ quality of life.

NEWS

Context for the News

Blood cancer, particularly large B-cell lymphoma, is a fast-growing and challenging disease that affects certain white blood cells. Traditional treatments may not always be effective, leading to the need for more advanced therapies. Car T-cell therapy, like liso-cel, represents a significant advancement in cancer treatment, utilizing the patient’s own immune cells to fight the disease.

The approval of liso-cel by the NHS comes after the manufacturer, Bristol Myers Squibb, offered an improved commercial arrangement. This decision is expected to provide patients with more treatment options and potentially reduce the time spent in hospitals, as it can be administered as an outpatient treatment. The response from medical professionals and organizations like Blood Cancer UK has been overwhelmingly positive, highlighting the importance of continued research and investment in new treatments.

The availability of this treatment underscores the NHS’s commitment to providing the best possible care for cancer patients and marks a significant milestone in the fight against blood cancer.

Main Story

Hundreds of people in England with aggressive blood cancer are set to benefit from an innovative new treatment, Lisocabtagene maraleucel (also known as liso-cel or Breyanzi), which has been recommended for NHS use.

  • Car T-cell Therapy: This treatment involves modifying a patient’s T-cells in a laboratory to target and kill cancer cells. The engineered cells are then reintroduced into the patient’s body as a one-off personalised treatment.
  • Approved for Large B-cell Lymphoma: The treatment is recommended for patients with large B-cell lymphoma, a fast-growing cancer affecting certain white blood cells, especially when the disease has not responded to initial treatment or returned within 12 months.
  • Impact and Benefits: The decision is expected to benefit nearly 600 patients annually. Trials suggest that liso-cel significantly delays disease progression, with patients living more than twice as long without their disease worsening compared to standard care.
  • Hope for Patients: Helen Knight, director of medicines evaluation at Nice, expressed optimism about the treatment, noting it offers hope and could reduce time spent in hospitals, potentially being given as an outpatient treatment.
  • Improved Commercial Arrangement: The new guidance comes after the manufacturer, Bristol Myers Squibb, offered an improved commercial arrangement to the NHS on the £297,000 list price per treatment.
  • NHS Commitment: Professor Peter Johnson, national director for cancer at NHS England, highlighted the NHS’s dedication to funding the best cancer care and welcomed the availability of this treatment for more patients with advanced blood cancers.
  • Blood Cancer UK’s Reaction: Josh Hill, policy officer at Blood Cancer UK, welcomed the decision, noting it provides more treatment options and highlights the importance of research and investment in developing new treatments.
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