Redefining
Cancer
Treatment
Redefining
Cancer
Treatment
Price ranges for Black Seed Oil.
Small Bottles (100ml): £8.90 to £14.99
Medium Bottles (250ml to 500ml): £19.90 to £55.00
Large Bottles (1 Litre): £77.00 to £139.90
These prices can vary based on factors like the oil’s quality, brand, and whether it is organic or cold-pressed.
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Blackseed oil, derived from Nigella sativa seeds, contains thymoquinone (TQ) as its primary bioactive constituent. TQ demonstrates pleiotropic effects, interacting with various molecular targets and exhibiting a wide range of biological activities.
Molecular Mechanisms: TQ modulates several key signalling pathways, including NF-κB, PI3K/Akt, and MAPK cascades, which are often dysregulated in cancer cells. This modulation influences gene expression related to inflammation, cell survival, apoptosis, and cell cycle regulation.
Anti-cancer Properties: Preclinical studies have revealed promising anti-cancer effects of TQ, including inhibition of cell proliferation, induction of apoptosis, and suppression of metastasis in various cancer cell lines. However, clinical evidence in humans remains limited and requires further investigation.
Metabolic Interactions: TQ’s impact on cancer metabolism is complex and not fully elucidated. Emerging research suggests potential effects on glucose metabolism, mitochondrial function, and energy homeostasis. TQ may influence key metabolic regulators such as AMPK, potentially altering cancer cell metabolism.
Key Research Findings: A comprehensive review published in Drug Discovery Today (2019) highlighted TQ’s multi-faceted anti-cancer potential. The study emphasized TQ’s ability to induce apoptosis, inhibit angiogenesis, and modulate the tumor microenvironment in in vitro and in vivo models. However, the authors stressed the critical need for well-designed clinical trials to confirm these findings in human patients.
Metabolic Theory of Cancer: TQ’s influence on cellular signalling pathways like AMPK, known to regulate energy homeostasis, suggests a potential link to the metabolic theory of cancer. This theory proposes that cancer arises from mitochondrial dysfunction and altered cellular metabolism. While TQ’s effects on metabolic pathways are intriguing, direct evidence supporting its role in targeting cancer metabolism according to this specific theory is currently lacking and requires further investigation.
Typical dosages range from 1 to 2 teaspoons of oil per day. However, there is no established standard dosage, and more research is needed to confirm its efficacy and safety for various health conditions.
Preliminary clinical trials investigating TQ in cancer warriors have used varying doses, typically ranging from 250 mg to 2 g per day, administered orally.
However, determining a safe and effective dosage requires further rigorous clinical research, including dose-escalation studies and long-term safety assessments.
If you plan on taking black seed oil as part of your metabolic therapy, it would be advisable to speak with your healthcare provider.
Breast Cancer, Colorectal Cancer, Leukemia, Lung Cancer, Ovarian Cancer, Prostate Cancer
While Blackseed oil is generally well-tolerated at low doses, it is not without potential side effects.
Common mild side effects may include
High doses or prolonged use may pose risks, particularly in individuals with certain medical conditions (e.g., bleeding disorders, low blood pressure) or those taking specific medications (e.g., blood thinners, diabetes medications).
Research on Blackseed oil in combination with conventional cancer therapies is limited but growing. Some preclinical studies suggest potential synergistic effects with certain chemotherapy drugs, enhancing their efficacy or reducing side effects.
For example, TQ has shown promise in sensitising resistant cancer cells to conventional treatments. However, clinical evidence in humans is lacking, and potential interactions with specific cancer therapies are not fully understood.
Several factors are worth noting:
Enhanced Quality of Life: A recent study found that lung cancer patients who received Nigella sativa supplementation alongside chemotherapy experienced a significant improvement in their quality of life compared to those receiving chemotherapy alone. This improvement was measured using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life (QLQ-C30) questionnaire13.
Increased IFN-γ Levels: The same study showed that Nigella sativa supplementation increased interferon-gamma (IFN-γ) levels, which can enhance immune function and potentially contribute to better overall health outcomes for cancer patients13.
Potential Side Effects: While generally considered safe, Black Seed Oil can cause side effects such as nausea, bloating, and allergic reactions. These side effects might impact quality of life if not managed properly.
Complementary Therapy: As a complementary therapy, Black Seed Oil may help mitigate some of the adverse effects of conventional cancer treatments, potentially leading to an improved quality of life by reducing symptoms like fatigue, nausea, and pain.
Cancer warriors taking Black Seed Oil may experience an improvement in their quality of life due to enhanced immune function and reduced side effects from chemotherapy.
However, individual responses can vary, and more research is needed to fully understand its long-term benefits.
We’ve done our best to include as much information as possible for this supplement.
If you have any other questions, please send us a message or join our Skool Group and ask our knowledgeable and friendly community.
Blackseed oil is generally available as a dietary supplement in health food stores, pharmacies, and online retailers. Its regulatory status and accessibility may vary depending on the country. In many Western countries, it is classified as a food supplement and is widely accessible without a prescription.
Determining the specific patient demographic for which Black Seed Oil (Nigella sativa) would work best in cancer treatment is challenging due to the limited availability of human clinical trials.
However, based on existing research, here are some insights:
Cancer Types: Black Seed Oil has shown potential in treating various types of cancer, including breast, colon, lung, pancreatic, liver, fibrosarcoma, prostate, and cervix cancers. This suggests it could be beneficial for patients with these types of cancers45.
Age and Health Status: While there is no specific age group identified, patients with a generally healthy immune system might benefit more from its immunomodulatory effects. However, more research is needed to confirm its efficacy across different age groups.
Complementary Therapy: Black Seed Oil may be more effective as a complementary therapy, enhancing the effects of chemotherapy and radiation by potentially sensitizing cancer cells to these treatments35. This could be beneficial for patients undergoing conventional cancer therapies.
Traditional Use: Historically, Black Seed Oil has been used in traditional medicine across various cultures, suggesting its potential use in diverse patient demographics. However, modern clinical trials are necessary to establish its safety and efficacy in specific populations.
In summary, while Black Seed Oil shows promise for various cancer types, its effectiveness across different patient demographics remains speculative without comprehensive human clinical trials.
Research highlights several potential pathways and factors that could influence resistance:
Cell Line Variability: Studies have shown that the cytotoxic effects of Black Seed Oil extracts vary across different tumour cell lines. For example, the ethyl acetate extract was more effective against the BSR cell line, while the essential oil was more effective against the P815 cell line1. This variability suggests that some cancer cells may develop resistance based on their genetic makeup or cellular characteristics.
Epigenetic Adaptation: Black Seed Oil, particularly thymoquinone (TQ), targets epigenetic regulators like UHRF1, DNMT1, and HDAC14. Cancer cells might develop resistance by adapting their epigenetic profiles to counteract these effects.
Signalling Pathways: TQ modulates multiple signalling pathways, including NF-κB, PI3K/Akt, and VEGF7. Resistance could arise if cancer cells develop mutations or compensatory mechanisms that bypass these pathways.
Apoptotic Resistance: TQ induces apoptosis by modulating pro-apoptotic and anti-apoptotic proteins like Bcl-27. Cells that develop resistance to apoptosis could limit the effectiveness of Black Seed Oil.
Metabolic Adaptation: Cancer cells may adapt metabolically to resist the cytotoxic effects of TQ by altering their detoxification pathways or energy metabolism.
Specific resistance mechanisms are not well-documented and cancer cells may develop resistance through genetic variability, epigenetic adaptation, signalling pathway modifications, apoptotic resistance, or metabolic changes. Further research is needed to fully understand these mechanisms and develop strategies to overcome them.
Preclinical studies on Black Seed Oil (Nigella sativa) and its main bioactive compound, thymoquinone (TQ), in cancer treatment:
Preclinical Studies on Anticancer Effects:
In Vivo Studies: A study using the DBA2/P815 mouse model showed that injecting Black Seed Oil into the tumour site significantly inhibited solid tumour development and reduced liver metastasis. Tumour volumes were significantly reduced after 30 days of treatment with essential oil injections every 48 hours2.
In Vitro Studies: Various extracts of Nigella sativa, including essential oil and ethyl acetate extracts, have demonstrated cytotoxic effects against several tumour cell lines, such as P815 and BSR2.
Mechanisms of Action:
Apoptosis and Cell Cycle Arrest: TQ induces apoptosis in cancer cells by modulating pro-apoptotic and anti-apoptotic proteins and arresting the cell cycle at the G1 phase25.
Epigenetic Modulation: TQ targets epigenetic regulators like UHRF1, DNMT1, and HDAC1, which are involved in cancer cell proliferation and apoptosis5.
Synergistic Effects with Conventional Therapies:
References:
–1 Frontiers in Pharmacology: Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment.
–2 SciELO: Anti-tumor properties of blackseed (Nigella sativa L.) extracts.
–3 PMC: Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment.
–5 PMC: The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy.
Information on active clinical trials specifically investigating Blackseed oil in cancer treatment is limited. See clinicaltrials.gov for up to date information.
Black Seed Oil (Nigella sativa) in cancer treatment is not well-documented.
Research highlights several key mechanisms and pathways that could be relevant:
Epigenetic Modulation: Black Seed Oil, particularly through its active compound thymoquinone (TQ), targets epigenetic regulators like UHRF1, DNMT1, and HDAC1, which are involved in cancer cell proliferation and apoptosis1. Variations in genes related to these epigenetic pathways might affect the oil’s efficacy.
Tumour Suppressor Genes: TQ modulates tumour suppressor genes, such as PTEN, which plays a crucial role in inhibiting the PI3K/Akt pathway3. Genetic alterations affecting PTEN expression or function could influence the effectiveness of Black Seed Oil.
Apoptotic Pathways: The oil induces apoptosis by modulating pro-apoptotic and anti-apoptotic proteins like Bax, Bcl-2, and Bcl-xL3. Genetic variations in these pathways might impact how well Black Seed Oil induces apoptosis in cancer cells.
Detoxification Genes: TQ influences phase I and II enzymes involved in detoxification, such as glutathione S-transferase (GST)24. Genetic polymorphisms in these enzymes could affect the metabolism and efficacy of Black Seed Oil.
While specific genetic markers are not identified, variations in genes related to epigenetic regulation, tumour suppression, apoptosis, and detoxification could potentially influence the effectiveness of Black Seed Oil in cancer treatment.
Explore the fascinating world of molecular hydrogen (H₂) and its emerging role as a supportive treatment for cancer. Drawing on
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Apoptosis, or programmed cell death, is a natural process where cells self-destruct when they are damaged or no longer needed. This is crucial for maintaining healthy tissues and preventing diseases like cancer.
Drugs and supplements that induce apoptosis help eliminate cancerous cells by triggering this self-destruct mechanism, ensuring that harmful cells are removed without damaging surrounding healthy tissue.
Understanding and harnessing apoptosis is vital in the fight against cancer, as it targets the root cause of the disease at the cellular level.
Cell proliferation is the process by which cells grow and divide to produce more cells. While this is essential for growth and healing, uncontrolled cell proliferation can lead to cancer.
Drugs and supplements that inhibit cell proliferation help prevent the rapid multiplication of cancerous cells, slowing down or stopping the progression of the disease.
By targeting the mechanisms that drive cell division, these treatments play a vital role in controlling and potentially eradicating cancer.
Cancer cells often hijack specific biological pathways to grow and spread. Drugs and supplements that target these pathways can disrupt the cancer cell’s ability to survive and multiply.
By focusing on the unique mechanisms that cancer cells use, these treatments can be more effective and cause fewer side effects compared to traditional therapies.
Targeting specific pathways is a key strategy in precision medicine, offering a tailored approach to combat cancer at its core.
Angiogenesis is the process by which new blood vessels form, supplying nutrients and oxygen to tissues. Cancer cells exploit this process to fuel their growth and spread.
Drugs and supplements that inhibit angiogenesis can effectively starve cancer cells by blocking the formation of these new blood vessels.
By cutting off the supply lines that tumors rely on, angiogenesis inhibitors play a crucial role in controlling and potentially shrinking cancerous growths.
Immunotherapy harnesses the power of the body’s immune system to combat cancer. By boosting or restoring the immune system’s natural ability to detect and destroy cancer cells, immunotherapy offers a targeted and effective approach to treatment.
Drugs and supplements that support immunotherapy can enhance the immune response, making it more efficient at identifying and attacking cancer cells.
This innovative approach not only helps in treating cancer but also reduces the risk of recurrence, providing a powerful tool in the fight against this disease.
Inflammation is the body’s natural response to injury or infection, but chronic inflammation can contribute to the development and progression of cancer.
Drugs and supplements with anti-inflammatory properties help reduce inflammation, thereby lowering the risk of cancer and other chronic diseases.
By targeting the inflammatory processes, these treatments can help maintain a healthier cellular environment and prevent the conditions that allow cancer to thrive.
