The Flawed Foundation of Modern Oncology

The National Cancer Institute defines cancer as “a genetic disease caused by DNA mutations.” But mounting evidence reveals this somatic mutation theory collapses under scrutiny:

• Many aggressive tumours show zero driver mutations

• Healthy tissues accumulate thousands of mutations without becoming cancerous

• Nuclear transfer experiments prove corrupted cytoplasm (not mutated DNA) drives uncontrolled growth

The smoking gun? Transplanting a cancer cell’s nucleus into healthy cytoplasm produces normal cells. Reverse the process, and healthy DNA becomes cancerous. This proves mitochondrial dysfunction, not genetic mutations, is cancer’s true catalyst.

The Metabolic Engine of Cancer

Tumours operate on two fermentable fuels:

1. Glucose (via cytoplasmic glycolysis → lactic acid)

2. Glutamine (via mitochondrial glutaminolysis → succinic acid)

Unlike healthy cells that efficiently burn fat/ketones through oxidative phosphorylation, cancer cells:

• Develop insulin hypersensitivity to hoard glucose

• Store unused fats as cytoplasmic lipid droplets

• Require 18x more glucose than normal cells

This explains why PET scans easily locate tumours – they’re radioactive glucose black holes.

Evolutionary Mismatch: Why Modern Diets Feed Cancer

Our Palaeolithic ancestors:

• Lived in chronic ketosis from meat/marrow/fat consumption

• Had cancer rates near zero (per anthropological records)

• Died primarily from injury/infection, not chronic disease

Modern mismatch factors:
🍩 Carbohydrate overload: Average American consumes 57kg annual added sugar
💊 Pharmaceutical disruption: 75% of common drugs impair mitochondrial function
🛋️ Sedentary lifestyles: Muscle glucose sequestration prevents tumours from hijacking fuel

Metabolic Warfare: Starving Cancer Strategically

Effective treatment requires dual fuel restriction:

Clinical wins:

• Glioblastoma patients show 50% longer survival when combining keto + lower-dose chemo

• Breast cancer trials demonstrate enhanced radiation efficacy with GKI ≤ 2

Quantifying Success: The Glucose-Ketone Index

Optimal therapeutic zone: GKI ≤ 2
(Glucose mmol/L ÷ Ketone mmol/L)

Achieving this requires:

1. Continuous glucose monitor

2. Blood ketone meter

3. Strategic carb restriction (<30g/day)

4. Moderate protein intake (1g/kg lean mass)

Overcoming Institutional Resistance

Despite compelling evidence, three barriers persist:

1. Funding bias: 93% of NCI grants focus on genetic research

2. Pharmaceutical economics: Metabolic therapies aren’t patentable

3. Medical education: Doctors receive ~7 hours average nutrition training

Patient empowerment strategies:

• Demand GKI monitoring during treatment

• Combine standard care with metabolic therapy

• Join clinical trials at metabolic research centres

A Metabolic Roadmap Forward

Prevention Protocol:

• Maintain GKI 6-8 through cyclical keto

• Weekly 36-hour fasts

• Resistance training 3x/week

Treatment Protocol:

• Target GKI 1-2 with medical supervision

• Combine pulsed chemotherapy with Don cycles

• Monitor tumour lipids via MRI (sign of metabolic stress)

Key Resources:

• Glucose-Ketone Index Calculator

• Cancer as a Metabolic Disease (Seyfried’s Textbook)

• Metabolic Terrain Institute for Health

The future of oncology lies not in hunting mythical “cancer genes,” but in respecting our evolutionary metabolic design. When we starve tumours of their preferred fuels while nourishing healthy cells, we turn cancer from a death sentence into a manageable condition.